Inter coach Simone Inzaghi has backed his side after the defeat in Bologna, but admits the Scudetto was out of the hands of the Nerazzurri.
Milan returned to Serie A with a win over Lazio on Sunday, and on Wednesday, two minutes and 53 seconds later, Inter Milan's Ivan Parisis started a positive response from star Diourano del Aara.
It was the Nerazzurri's fastest league goal of the season, but Marko Arnautovic equalized with his former club and his 13th league goal of the season, his best in a single season in the top five European leagues.
Inter lost 2-1 thanks to a mistake by substitute Nicolas Sanson, who had just nine minutes left in the Scudetto, four games behind them, two points behind.
Milan have an excellent record against their neighbors, with Inzaghi admitting he is no longer in control of the club.
"Now I know there is a team of heroes who will do everything possible to finish this championship hard, but now we are no longer the masters of our destiny," he told reporters after the match.
Inzaghi has refused to let go of his hopes of winning the trophy after losing to Bologna, who have not lost at home to Serie A 15 times in the past.
"With four games left, I see it as a surprise trophy that has been played to the end," he said.
"There are 12 points left to capture and anything can happen."
Inzaghi could not control Sansone's winning goal as he could not control Perisic's pass. He is the first goalkeeper to reach Serie A this season due to injury.
"It was disappointing to be back to normal after this defeat," he told DAZN. "The mood was not the best and Radu made a mistake like me or a striker and a midfielder.
"When a goalkeeper makes a mistake, everything becomes clearer. Now we have to respond to a fiery defeat and face the same fate, knowing that we are no longer the masters of our destiny."
Inter Milan will try to respond to their Scudetto push when they arrive in Udinese on Sunday.